Paromomycin is an aminoglycoside antibiotic isolated from
Streptomyces rimosus. It targets a variety of gram-negative and
gram-positive bacteria as well as several protozoan species. It
displays activity similar to that of neomycin.
Aminoglycoside antibiotics are composed of amino groups attached
to glycosides. They bind the 30s ribosomal subunit, causing
misreading of the mRNA sequence and inhibition of translocation.
Consequently, protein synthesis is inhibited.
Paromomycin sulfate is freely soluble.
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