Human

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Human globular ACRP-30 – Animal Free
300-882P

 The globular subunit of adipocyte complement-related protein of 30 kDa (ACRP-30) is a naturally occurring cleavage product of adiponectin, a protein made exclusively by adipocytes. ACRP-30 is an abundant serum protein and plays an important role in hyperglycemia, insulin resistance, and fatty acid oxidation. ACRP-30 signals through adiponectin receptor 1 (AdipoR1) and adiponectin receptor 2 (AdipoR2).

This product is produced using Animal Free raw components and processes, in a non-mammalian system.

Ships ambient. Store frozen at -20 to -10°C

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Human Placenta Growth Factor-3 (PlGF-3) – Animal Free
300-942P

Placenta growth factor (PlGF) is a member of the vascular endothelial growth factor (VEGF) family and promotes endothelial cell growth and angiogenesis.  PlGF is secreted as a homodimer and may also form a heterodimer with VEGF.  PlGF is detected in the placenta, heart, lungs, thyroid, and adipose tissues.  Circulating PlGF levels are correlated with colorectal and renal cancers, as well as atherosclerosis and ischemic heart disease.  There are four alternatively spliced PlGF isoforms (PlGF-1, PlGF-2, PlGF-3, and PlGF-4), each with unique secretion patterns and heparin-b

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Human/Mouse Transforming Growth Factor-beta 3 (TGF-β 3) – Animal Free
300-941P

Transforming growth factors (TGFs) are multifunctional peptides that regulate growth and differentiation in most cell types. The TGF-β family of proteins signal through serine/threonine kinase receptors. TGF-β isoforms (TGF-β1, -β2, and –β3) have overlapping, yet distinct biological actions in developing and adult tissues. TGF-β3 is an important factor in regulating cell adhesion and accelerating wound repair. TGF-β3 also functions during osteoblast proliferation, chemotaxis, and collagen synthesis.

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Human/Mouse Neurotrophin-3 (NT-3) – Animal Free
300-940P

Neurotrophin-3 (NT-3) is an important member of the nerve growth factor (NGF) family of proteins. NT-3 promotes the growth, survival, and differentiation of neurons and synapses in the peripheral and central nervous systems. The receptor tyrosine kinase TrkC exclusively binds in high-affinity to NT-3. NT-3 also signals through the receptor tyrosine kinase TrkB, and through the low affinity nerve growth factor receptor (LNGFR).

This product is produced using Animal Free raw components and processes, in a non-mammalian system.

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Human/Mouse Indian Hedgehog (IHH) – Animal Free
300-939P

 Indian hedgehog (IHH) is an essential signaling factor that is secreted in the gut, cartilage, and bone during embryonic development. IHH acts through the patched (PTC) receptor to induce transcriptional changes important for bone and cartilage development. IHH also induces the expression of parathyroid hormone-related peptide (PTHrP), which in turn mediates IHH activity during chondrocyte differentiation, forming a negative feedback loop.

This product is produced using Animal Free raw components and processes, in a non-mammalian system.

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Human/Mouse/Rat Growth and Differentiation Factor-11 (GDF-11) – Animal Free
300-938P

Growth differentiation factor 11 (GDF-11), also known as bone morphogenetic protein 11 (BMP-11), is a regulator of cell growth and differentiation during muscular and neural development. GDF-11 binds the transforming growth factor-beta receptors ALK4, ALK5, and ALK7 to activate SMAD signaling. In adults, exogenous GDF-11 promotes cardiomyocyte regeneration to reverse age-related cardiac hypertrophy.

This product is produced using Animal Free raw components and processes, in a non-mammalian system.

Ships ambient. Store frozen at -20 to -10°C

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Human/Mouse/Rat Bone Morphogenetic Protein-2 (BMP-2) – Animal Free
300-936P

Bone morphogenetic protein 2 (BMP-2 or BMP2) is a member of the bone morphogenetic protein (BMP) family and functions as a potent inducer of bone and cartilage development. BMP proteins are synthesized as large precursor molecules which are cleaved by proteolytic enzymes. Bioactive BMP-2 consists of forming a homodimer or a heterodimer with a related BMP, such as BMP-7. BMP-2 signals through type I and type II receptor tyrosine kinases in conjuction with SMAD proteins to directly promote osteoblast differentiation.

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Human/Mouse/Rat Activin A – Animal Free
300-935P

 Activin A is a member of the transforming growth factor beta (TGF-β) family of proteins and functions to stimulate follicle-stimulating hormone (FSH) secretion.  Activins are produced in many tissue types including the skin, gonads, lungs, and pituitary gland.  Activins interact with receptor type I and type II serine/threonine protein kinases, to activate SMAD signaling and regulate diverse cellular functions, such as cell proliferation, differentiation, wound healing, apoptosis, and metabolism.  Activin A is a homodimer comprised of two activin βA chains.

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Human Interleukin-15 (IL-15) – Animal Free
300-902P

 Interleukin 15 (IL-15) is a widely expressed proinflammatory cytokine that is structurally and functionally related to interleukin 2 (IL-2). IL-15 signals through JAK kinases to activate STAT3, STAT5, and STAT6 transcription factors. IL-15 regulates the activation of T cells, neutrophils, and macrophages, and is a stimulatory cytokine promoting dendritic cell function. IL-15 expression is dysregulated in chronic inflammatory disorders, including rheumatoid arthritis, psoriasis, and pulmonary inflammatory diseases.

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Human Interleukin-11 (IL-11) – Animal Free
300-901P

Interleukin 11 (IL-11) is a member of the gp130 family of cytokines. IL-11 functions to promote hematopoietic stem cell proliferation and megakaryocyte differentiation. In non-hematopoietic cell populations, IL-11 stimulates acute-phase proteins, modulates the development of immunoglobulin-producing B cells, and regulates bone turnover. IL-11 binds the IL-11Rα receptor to activate JAK downstream signaling. Human IL-11 shows activity on murine cells.

This product is produced using Animal Free raw components and processes, in a non-mammalian system.

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Human Neuregulin 1-beta (NRG1-β) – Animal Free
300-900P

 Neuregulin 1-beta (NRG1-β) is one of many alternatively-spliced isoforms of the NRG1 gene and contains a soluble EGF-like domain. The EGF-like domain of NRG1-β signals through the ErbB2, ErbB3, and ErbB4 receptor tyrosine kinases. NRG1-β is an important growth factor involved in neuroinflammation, nerve regeneration, and cardiovascular processes.

This product is produced using Animal Free raw components and processes, in a non-mammalian system.

Ships ambient. Store frozen at -20 to -10C.

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Product 100 μg $98500 μg $2281Mg Inquire5Mg Inquire10Mg Inquire

Human Growth Hormone – Animal Free
300-899P

 Growth hormone (GH) is an important mitogenic growth factor that is synthesized, stored, and secreted by somatotropic cells of the anterior pituitary gland. GH stimulates growth, cell reproduction, and cell regeneration. In children, GH deficiencies can cause short stature, growth failure, and delayed sexual maturity. Adult GH deficiency presents with reduced lean body mass, increased adiposity, reduced muscle strength, and ultimately premature mortality.

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Product 200 μg $981Mg $2285Mg Inquire10Mg Inquire

Human Leptin – Animal Free
300-898P

 Leptin is a hormone that is produced by adipose tissue and plays critical roles in the physiologic regulation of body weight. Leptin acts through the leptin receptor (LEPR) to regulate adipose mass by inhibiting hunger and balancing energy usage. Leptin mutations cause severe hereditary obesity and hypogonadism in rodents and humans. Leptin also has thermogenic actions, regulates enzymes of fatty acid oxidation, and is involved in hematopoiesis, angiogenesis, wound healing, inflammation, and immune responses.

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Human Fibroblast Growth Factor-4 (FGF-4) – Animal Free
300-897P

 Fibroblast growth factor 4 (FGF-4) is a secreted growth factor that is predominantly expressed during bone morphogenesis and embryonic limb development.  FGF-4 is an important growth regulator for stem cells, fibroblasts, and endothelial cells.  FGF-4 contains a single N-linked glycosylation signal.  In-vitro studies suggest that unglycosylated FGF-4 is cleaved into 13 kDa and 15 kDa truncated proteins that have greater biological activity than the wild type 19 kDa FGF-4 protein.  Human FGF-4 shares high homology and is cross-reactive with mouse FGF-4. 

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Human Galectin-1 – Animal Free
300-896P

Galectin-1 belongs to the lectin family of carbohydrate binding proteins and binds glycans as both a monomer and a homodimer. Galectin-1 is produced in peripheral lymphoid organs and inflammatory sites. Galectin-1 plays important roles in acute and chronic inflammatory processes, cell growth, cell proliferation, and induces apoptosis of activated T cells. Galectin-1 also modulates cytokine secretion and inhibits pro-inflammatory cytokine production.

This product is produced using Animal Free raw components and processes, in a non-mammalian system.

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Human Fibroblast Growth Factor-acidic (FGF-acidic / FGF-1) – Animal Free
300-895P

 Acidic fibroblast growth factor (FGF-acidic), also known as FGF-1, is a potent inducer of DNA synthesis, cell proliferation, and has chemotactic activities.  FGF-acidic regulates cardiogenesis through protein kinase C signaling.  FGF-acidic also functions as an insulin sensitizer and mediates adipose tissue remodeling.  High serum levels of FGF-acidic are associated with type 2 diabetes mellitus (T2DM), suggesting a pathogenic role of FGF-acidic during T2DM. 

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Human Myostatin – Animal Free
300-894P

Myostatin, also known as GDF-8, is a conserved member of the TGF-beta superfamily. Myostatin is an essential regulator of skeletal muscle mass and cardiac muscle development and function. Myostatin is a secreted protein that negatively regulates skeletal muscle growth by determining muscle fiber number and size. Myostatin binds one of the two activin type II receptors (ACTRIIA or ACTRIIB) to activate SMAD signaling. Myostatin also activates MAPK signaling through TAK1-MKK6 and Ras pathways.

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Human Fibroblast Growth Factor-9 (FGF-9) – Animal Free
300-893P

Fibroblast growth factor 9 (FGF-9) is a mitogen and survival factor for nerve and mesenchymal cells. FGF-9 functions as an autocrine and paracrine factor to support the growth and survival of motor neurons and prostate tissue. FGF-9 expression in the gonad is also necessary for sex determination. 

This product is produced using Animal Free raw components and processes, in a non-mammalian system.

Ships ambient. Store frozen at -20 to -10C.

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Human Amphiregulin (AREG) – Animal Free
300-891P

Amphiregulin (AR) is a member of the epidermal growth factor (EGF) family.  AR is an autocrine growth factor and functions to regulate cell proliferation and survival through binding the EGF receptor (EGFR).  AR promotes the proliferation of neural stem cells and epithelial cells, including keratinocytes and mammary epithelium. Up-regulated at puberty, AR promotes ductal outgrowth and mammary branching. In the liver, AR functions as a mitogen and prevents hepatocyte apoptosis.

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