Human

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Human Interleukin-31 (IL-31) – Animal Free
300-890P

Interleukin 31 (IL-31) is an immunoregulatory cytokine that is expressed by activated type 2 T helper (Th2) cells.  IL-31 signals through a heterodimer receptor consisting of the IL-31 Receptor A (IL-31RA) and the oncostatin M receptor (OSMR), which are expressed on monocytes, epithelial cells, and keratinocytes.  IL-31 promotes allergic reactions and inflammatory skin diseases.

This product is produced using Animal Free raw components and processes, in a non-mammalian system.

Ships ambient. Store frozen at -20 to -10C.

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Human Fibroblast Growth Factor-6 (FGF-6) – Animal Free
300-889P

Fibroblast growth factor 6 (FGF-6) is a heparin-binding growth factor that is expressed in epithelial and mesenchymal lineages. FGF-6 binds and signals through the FGF receptors FGFR1, FGFR2, and FGFR4. FGF-6 functions as a mitogen for vascular endothelial cells and fibroblasts. FGF-6 is also an important factor driving muscle differentiation and regeneration.

This product is produced using Animal Free raw components and processes, in a non-mammalian system.

Ships ambient. Store frozen at -20 to -10C.

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Human Fibroblast Growth Factor-5 (FGF-5) – Animal Free
300-888P

Fibroblast growth factor 5 (FGF-5) is a secreted heparin-binding growth factor that binds to FGF receptors 1 and 2 (FGFR1 and FGFR2). FGF-5 is expressed in the mesenchyme, skeletal muscles, central nervous system, and hair follicles to promote cell differentiation and proliferation. FGF-5 functions as a regulatory factor during hair elongation and skeletal muscle development.

This product is produced using Animal Free raw components and processes, in a non-mammalian system.

Ships ambient. Store frozen at -20 to -10C.

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Product 100 μg $98250 μg $228500 μg Inquire1Mg Inquire

Human Apolipoprotein-E4 (APO-E4) – Animal Free
300-887P

Apolipoprotein E (APO-E) is a chylomicron lipoprotein that is necessary for the metabolism of lipoproteins and lipid transport.  The APO-E gene has three alleles, termed APO-E2, APO-E3, and APO-E4.  The APO-E allelic proteins differ by only one or two amino acids, but have different biological structures and functions.  APO-E3 is the most common and neutral allele.  The APO-E4 allele is associated with an increased risk for Alzheimer’s Disease (AD) and coronary artery disease (CAD).  The APO-E4 protein morphology decreases the ability of APO-E4 to clear beta-amyloid

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Human WNT1-inducible-signaling pathway protein-2 (WISP-2 / CTGF-L) – Animal Free
300-886P

WNT1-inducible-signaling pathway protein 2 (WISP-2) is a member of the CYR61/CTGF/NOV (CCN) family of regulatory factors. WISP-2 is expressed in ectodermal, mesodermal, and endodermal lineages, including primary osteoblasts, fibroblasts, mesenchymal stem cells, and adipogenic precursor cells. WISP-2 is a canonical WNT ligand that regulates cell proliferation, adhesion, and metastasis. Secreted WISP-2 promotes mesenchymal precursor cell proliferation and maintains them in an undifferentiated state.

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Human IL-1 Receptor Antagonist (IL-1 RA / IL-1F3) – Animal Free
300-885P

 Interleukin-1 receptor antagonist (IL-1RA) binds the interleukin 1 receptor (IL-1R) to antagonize interleukin 1 alpha and beta signaling.  IL-1RA is secreted by immune cells, epithelial cells, hepatocytes, and adipocytes to inhibit IL-1-induced inflammation.  IL-1RA therapy is used to treat auto-inflammatory diseases such as diabetes and rheumatoid arthritis. 

This product is produced using Animal Free raw components and processes, in a non-mammalian system.

Ships ambient. Store frozen at -20 to -10C.

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Product 2 μg $9810 μg $228100 μg Inquire500 μg Inquire1Mg Inquire

Human Interleukin-1 alpha (IL-1α / IL-1F1) – Animal Free
300-884P

 Interleukin 1 alpha (IL-1α) is expressed by epithelial cells, activated macrophages, neutrophils, and endothelial cells to regulate immune responses. IL-1α signals through the IL-1 receptor, type 1 (IL-1R1) to activate the myeloid differentiation primary response 88 (MYD88) signaling pathway, which contains the cytoplasmic Toll/IL-1 receptor (TIR) domain adapter.

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Human Growth and Differentiation Factor-15 (GDF-15) – Animal Free
300-883P

Growth differentiation factor 15 (GDF-15) is a member of the transforming growth factor beta (TGF-β) family and is made by the placenta and cardiovascular tissues. GDF-15 regulates inflammatory and apoptotic pathways during cellular stress and injury. GDF-15 is emerging as a biomarker of early heart disease, such that increased levels of circulating GDF-15 are associated with an increased risk of developing heart failure.

This product is produced using Animal Free raw components and processes, in a non-mammalian system.

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Human Interleukin-17F (IL-17F) – Animal Free
300-881P

Interleukin 17F (IL-17F), a member of the IL-17 cytokine family, is secreted by activated CD4+ T cells and monocytes.  IL-17F binds the IL-17 receptor related molecule, IL17RC, to promote the production of the interleukin 6 (IL-6), interleukin 8 (IL-8), and granulocyte macrophage colony-stimulating factor (GM-CSF) cytokines.

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Human Insulin-like Growth Factor II (IGF-II) – Animal Free
300-880P

 Insulin-like growth factor II (IGF-II) is an important fetal growth hormone made by theca cells during gestation. IGF-II engages the IGF-I receptor (IGF1R) to mediate embryonic growth. IGF-II also binds the sink IGF-II receptor (IGF2R) leading to IGF-II degradation.

This product is produced using Animal Free raw components and processes, in a non-mammalian system.

Ships ambient. Store frozen at -20 to -10C.

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Human Fibroblast Growth Factor-21 (FGF-21) – Animal Free
300-879P

  Fibroblast growth factor 21 (FGF-21) is an endocrine hormone that regulates energy homeostasis and exerts cardioprotective functions during heart injury. FGF-21 is expressed in the liver, pancreas, heart, and adipose tissues. FGF-21 signaling is activated through the FGFR1c receptor and β-Klotho co-receptor. FGF-21 is an important regulator of glucose uptake and reduces cell apoptosis under stress conditions.

This product is produced using Animal Free raw components and processes, in a non-mammalian system.

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Human Interleukin-7 (IL-7) – Animal Free
300-878P

 Interleukin 7 (IL-7) is a hematopoietic cytokine that is an important regulator of B and T cell development. IL-7 is secreted by bone marrow and thymic stromal cells, dendritic cells, intestinal epithelial cells, hepatocytes, and keratinocytes. IL-7 signals through the interleukin 7 receptor (IL-7R) to promote the differentiation of hematopoietic stem cells into T cells, B cells, and natural killer cells. IL-7 is also a regulator of intestinal mucosal lymphocyte proliferation. Human and mouse IL-7 show species cross-reactivity.

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Human Endocrine Gland-Vascular Endothelial Growth Factor (EG-VEGF) – Animal Free
300-877P

 Endocrine gland-derived vascular endothelial growth factor (EG-VEGF) is an angiogenic growth factor that is expressed in the ovaries, testis, adrenal, and placental tissues. EG-VEGF has mitogenic, chemoattractive, and antiapoptotic functional roles. EG-VEGF signaling is mediated through binding the G protein-coupled receptors prokineticin receptor 1 (PKR1) and prokineticin receptor 2 (PKR2).

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Human Brain Derived Neurotrophic Factor (BDNF) – Animal Free
300-876P

Brain-derived neurotrophic factor (BDNF) is a nerve growth factor that binds two receptors, the low-affinity nerve growth factor receptor (LNGFR) and the tropomyosin receptor kinase B (TrkB), to support neuron growth and survival. BDNF expression in the hippocampus is essential for long-term memory storage and learning. Human, mouse, rat, and pig BDNF are cross-reactive.

This product is produced using Animal Free raw components and processes, in a non-mammalian system.

Ships ambient. Store frozen at -20 to -10C.

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Product 2 μg $9010 μg $207100 μg Inquire500 μg Inquire1Mg Inquire

Human/Feline Stromal Cell-Derived Factor-1 beta (SDF-1 β / CXCL12)
300-608

Stromal cell-derived factor-1 beta (SDF-1 β), also called CXCL12b, is one of two SDF-1 splice variants made by a wide variety of cells upon stimulation by inflammatory cytokines such as TNF, IL-1, and LPS. SDF-1 β signals through the G protein-coupled receptor CXCR4 to recruit activated leukocytes.

Ships ambient. Store frozen at -20 to -10C.

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Human/Mouse Transforming Growth Factor-beta 3 (TGF-β 3)
300-606

Transforming growth factors (TGFs) are multifunctional peptides that regulate growth and differentiation in most cell types. The TGF-β family of proteins signal through serine/threonine kinase receptors. TGF-β isoforms (TGF-β1, -β2, and –β3) have overlapping, yet distinct biological actions in developing and adult tissues. TGF-β3 is an important factor in regulating cell adhesion and accelerating wound repair. TGF-β3 also functions during osteoblast proliferation, chemotaxis, and collagen synthesis.

Ships ambient. Store frozen at -20 to -10C.

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Product 2 μg $9010 μg $207100 μg Inquire500 μg Inquire1Mg Inquire

Human/Mouse Neurotrophin-3 (NT-3)
300-605

Neurotrophin-3 (NT-3) is an important member of the nerve growth factor (NGF) family of proteins. NT-3 promotes the growth, survival, and differentiation of neurons and synapses in the peripheral and central nervous systems. The receptor tyrosine kinase TrkC exclusively binds in high-affinity to NT-3. NT-3 also signals through the receptor tyrosine kinase TrkB, and through the low affinity nerve growth factor receptor (LNGFR).

Ships ambient. Store frozen at -20 to -10C.

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Product 5 μg $9025 μg $90100 μg Inquire500 μg Inquire1Mg Inquire

Human/Mouse Indian Hedgehog (IHH)
300-604

Indian hedgehog (IHH) is an essential signaling factor that is secreted in the gut, cartilage, and bone during embryonic development. IHH acts through the patched (PTC) receptor to induce transcriptional changes important for bone and cartilage development. IHH also induces the expression of parathyroid hormone-related peptide (PTHrP), which in turn mediates IHH activity during chondrocyte differentiation, forming a negative feedback loop.

Ships ambient. Store frozen at -20 to -10C.

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Product 5 μg $9020 μg $207100 μg Inquire500 μg Inquire1Mg Inquire

Human/Mouse/Rat Growth and Differentiation Factor-11 (GDF-11)
300-603

 Growth differentiation factor 11 (GDF-11), also known as bone morphogenetic protein 11 (BMP-11), is a regulator of cell growth and differentiation during muscular and neural development. GDF-11 binds the transforming growth factor-beta receptors ALK4, ALK5, and ALK7 to activate SMAD signaling. In adults, exogenous GDF-11 promotes cardiomyocyte regeneration to reverse age-related cardiac hypertrophy.

Ships ambient. Store frozen at -20 to -10C.

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Human/Mouse Fibroblast Growth Factor-8 (FGF-8)
300-602

Fibroblast growth factor 8 (FGF-8) is a critical mitogenic factor that is required for normal development of the eye, ear, brain, and limb. FGF-8 functions broadly to promote cell proliferation, differentiation, and migration. Overexpression of FGF-8 increases tumor growth and angiogenesis. Human and mouse FGF-8 proteins show 100% homology.

Ships ambient. Store frozen at -20 to -10C.

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