Human

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Human Interleukin-1-alpha (IL-1α / IL-1F1)
300-197P

Interleukin-1 alpha (IL-1α) is constiutively expressed by epithlial cells, but can also be produced by most other cells upon stimulation. IL-1β and IL-1α are two distinct and independently regulated gene products that comprise IL-1 and signal through the Type 1 IL-1 receptor (IL-1R1). Although IL-1α is cell associated and IL-1β is secreted, they have nearly identical biological activity in that they induce adhesion molecule expression on epithelial cells, control fever induction, and play a role in arthritis and septic shock.

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Human Interleukin-1-beta (Animal Free)
300-810P

Interleukin-1-beta (IL-1β) is a proinflammatory cytokine produced in response to inflammatory agents by a variety of cells, including monocytes, macrophages, and dendritic cells (DCs). IL-1β and IL-1α are two distinct and independently regulated gene products that comprise IL-1 and signal through the Type 1 IL-1 receptor (IL-1R1). Although IL-1α is cell associated and IL-1β is secreted, they have nearly identical biological activity in that they induce adhesion molecule expression on epithelial cells, control fever induction, and play a role in arthritis and septic shock.

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Human Interleukin-1-beta (IL-1β)
300-145P

Interleukin-1-beta (IL-1β) is a proinflammatory cytokine produced in response to inflammatory agents by a variety of cells, including monocytes, macrophages, and dendritic cells (DCs). IL-1β and IL-1α are two distinct and independently regulated gene products that comprise IL-1 and signal through the Type 1 IL-1 receptor (IL-1R1). Although IL-1α is cell associated and IL-1β is secreted, they have nearly identical biological activity in that they induce adhesion molecule expression on epithelial cells, control fever induction, and play a role in arthritis and septic shock.

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Human Interleukin-10 (IL-10 Animal Free)
300-832P

Interleukin 10 (IL-10) is an anti-inflammatory cytokine mainly produced by macrophages and Th2 cells. IL-10 functions by inhibiting pro-inflammatory cytokines made by macrophages and regulatory T cells including, IFN-γ, TNF-α, IL-2, and IL-3, IL-4, and GM-CSF. IL-10 is also known to suppress antigen presentation on antigen presenting cells. While human IL-10 can act on murine cells, murine IL-10 cannot act on human cells. Recombinant human IL-10 is a non-glycosylated protein, containing 161 amino acids and having a molecular mass of 16.6 kDa.

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Human Interleukin-10 (IL-10)
300-135P

Interleukin 10 (IL-10) is an anti-inflammatory cytokine mainly produced by macrophages and Th2 cells. IL-10 functions by inhibiting pro-inflammatory cytokines made by macrophages and regulatory T cells including, IFN-γ, TNF-α, IL-2, and IL-3, IL-4, and GM-CSF. IL-10 is also known to suppress antigen presentation on antigen presenting cells. While human IL-10 can act on murine cells, murine IL-10 cannot act on human cells. Recombinant human IL-10 is a non-glycosylated protein, containing 161 amino acids and having a molecular mass of 16.6 kDa.

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Human Interleukin-11 (IL-11)
300-136P

Interleukin 11 (IL-11) is a pleotropic cytokine closely related to IL-6 in function, but is overall one of the lesser characterized interleukins. In hematopoietic cell populations, IL-11 is thought to induce megakaryocyte differentiation. In non-hematopoietic populations, IL-11 is thought to be able to stimulate hepatic acute-phase proteins. Human IL-11 can stimulate murine cells. Recombinant human IL-11 is a non-glycosylated protein, containing 179 amino acids and having a molecular mass of 19.3 kDa.

Ships ambient. Store frozen at -20 to -10C.

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Human Interleukin-13 (IL-13)
300-137P

Interleukin-13 (IL-13) is an important cytokine secreted from Th2 cells. The functions attributed to IL-13 overlap significantly with those of IL-4 (induces IgE secretion from B cells and inhibits expression of inflammatory cytokines such as IL-1β, TNF-α, IL-8 and IL-6), but differs from IL-4 in that IL-13 seems to link inflammatory response of immune cells to the pathophysiological changes in the surrounding non-immune cells. The receptor subunits of IL-13 consist of IL-4Rα, IL-13Rα1 and IL-13Rα2.

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Human Interleukin-15 (IL-15)
300-138P

Interleukin 15 (IL-15) is a widely expressed pro-inflammatory cytokine related to IL-2. IL-15 promotes activation of T cells, neutrophils and macrophages and is critical to dendritic cell function in several model systems. IL-15 has been shown to play a role in several inflammatory disorders, including rheumatoid arthritis, psoriasis and pulmonary inflammatory diseases. Emerging data suggests that IL-15 may serve as a good therapeutic target, as there appears to be a beneficial effect of IL-15 neutralization in models of psoriasis and diabetes.

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Human Interleukin-16 (IL-16)
300-139P

Interleukin 10 (IL-16) is produced primarily by CD4+ and CD8+ T cells and acts as a chemo -attractant for lymphocytes, monocytes, eosinophils, dendritic cells and Langerhans cells. Additionally, IL-16 has been reported to upregulate IL-2 receptor (CD25), induce progression of cells to the G1 phase and suppress HIV & SIV replication. Recombinant Human IL-16 is a non-glycosylated protein, comprised of 130 amino acids with a molecular weight of 13.5 kDa.

Ships ambient. Store frozen at -20 to -10C.

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Human Interleukin-17AF Heterodimer (IL-17AF Heterodimer)
300-141P

Interleukin-17AF (IL-17AF) is a member of the IL-17 family of proteins produced by a subset of T cells, called Th17, following stimulation with IL-23. Since IL-17AF is thought to signal through the IL-17RA receptor, its biological function is similar to that of IL-17A in that it induces the production of a variety of chemokines, in addition to airway neutrophilia. In regard to these functions, IL-17AF has less activity than the IL-17A homodimer but, greater activity than the IL-17F homodimer.

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Human Interleukin-17E (IL-17E, IL-25)
300-142P

Interleukin-17E (IL-17E), also commonly called IL-25, is a pro-inflammatory cytokine member of a six-species family of proteins (IL-17A-17F). IL-17F stimulates secretion of IL-8 and induces activation of NF-kappaB by binding to the receptor IL-17RB. Recombinant human Il-17E is a non-glycosylated, disulfide-linked, homodimer. The dimer consists of two 145 amino acid proteins and has a total molecular mass of 35.5 kDa.

 Ships ambient. Store frozen at -20 to -10C.

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Human Interleukin-19 (IL-19 Animal Free)
300-835P

Interleukin-19 (IL-19) is a member of the IL-10 family produced by resting B cells and monocytes, being up-regulated when monocytes are treated with GM-CSF or LPS. IL-19 shares a receptor complex with IL-20, and functional acts to induce IL-6 and TNF-α production by monocytes and promotes the Th2 response. Recombinant human IL-19 is a non-glycosylated protein, containing 155 amino acids and having a molecular mass of 17.9 kDa.

This product is produced using Animal Free raw components and processes, in a non-mammalian system.

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Human Interleukin-19 (IL-19)
300-144P

Interleukin-19 (IL-19) is a member of the IL-10 family produced by resting B cells and monocytes, being up-regulated when monocytes are treated with GM-CSF or LPS. IL-19 shares a receptor complex with IL-20, and functional acts to induce IL-6 and TNF-α production by monocytes and promotes the Th2 response. Recombinant human IL-19 is a non-glycosylated protein, containing 155 amino acids and having a molecular mass of 17.9 kDa.

Ships ambient. Store frozen at -20 to -10C.

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Human Interleukin-2 (IL-2)
300-146P

Interleukin-2, also known as T-cell Growth Factor, is an immunomodulatory cytokine produced by stimulated T-cells.  Its activity is signaled via interaction with the IL-2R receptor. Recombinant IL-2 produced in E.Coli is a single, non-glycosylated polypeptide chain containing 134 amino acids and having a molecular mass of 15,517 Daltons. Recombinant human IL-2 has a Ser substitute for Cysteine at position 126.

Ships ambient. Store frozen at -20 to -10°C

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Human Interleukin-2 (IL-2) – Animal Free
300-811P

Interleukin-2, also known as T-cell Growth Factor, is an immunomodulatory cytokine produced by stimulated T-cells. Its activity is signaled via interaction with the IL-2R receptor. Recombinant IL-2 produced in E.Coli is a single, non-glycosylated polypeptide chain containing 134 amino acids and having a molecular mass of 15,517 Daltons. Recombinant human IL-2 has a Ser substitute for Cysteine at position 126.

This product is produced using Animal Free raw components and processes, in a non-mammalian system.

Ships ambient. Store frozen at -20 to -10°C

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Human Interleukin-21 (IL-21 Animal Free)
300-818P

Interleukin-21 (IL-21) is a member of the common gamma-chain family of cytokines (includes IL-2, IL-4, IL-7, IL-9, IL-13, and IL-15) and is expressed by activated CD4+ T cells. IL-21 has a private receptor known as IL-21R, which is expressed on T, B, and NK cells. Within the B cell lineage, IL-21 regulates IgG1 production and cooperates with IL-4 for the production of multiple Ab classes in vivo. Initial studies have demonstrated that IL-21 has pleiotropic effects on the proliferation, differentiation, and effector functions of B, T, natural killer, and dendritic cells.

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Human Interleukin-22 (IL-22)
300-149P

Interleukin 22 (IL-22), also called IL-TIF, is an IL-10 family member, produced by activated dendritic cells and T lymphocytes. IL-22 signals via the IL-22R and IL-10R beta receptors to act as a potent mediator of teh cellular inflammatory response. Recombinant human IL-22 is a non-disulfide-linked homodimer, containing two 146 amino acids and having a total molecular mass of 33.6 kDa.

Ships ambient. Store frozen at -20 to -10C.

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Human Interleukin-29 (IL-29)
300-150P

Interleukin 29 (IL-29), also known as IFN gamma 1, is a type III interferon produced by virally infected cells. It is thought to play and important role in host defenses against multiple microbes and shares homology with IL-28. Recombinant human IL-29 is a non-glycosylated protein, containing 179 amino acids and having a molecular mass of 19.9 kDa.

Ships ambient. Store frozen at -20 to -10C.

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Human Interleukin-3 (Animal Free)
300-812P

Interleukin-3 (IL-3) is a cytokine produced by activated T-cells and mast cells. IL-3 is able to induce the differentiation of hematopoietic stem cells to precursor cells of myeloid lineage (erythrocytes, megakaryocytes, granulocytes, dendritic cells and monocytes). IL-3 also has functions in the nervous system and appears to be important in several chronic inflammatory diseases. Recombinant human IL-3 is a non-glycosylated protein, containing 133 amino acids and having a molecular mass of 15 kDa.

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