Mouse

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Mouse CD40 Ligand
300-300P

CD40 Ligand (CD40-L), or CD154, is a membrane glycoprotein and differentiation antigen expressed on the surface of T cells. The CD40-L stimulates B-cell proliferation and secretion of all immunoglobulin isotypes in the presence of cytokines. CD40-L has been shown to induce cytokine production and tumoricidal activity in peripheral blood monocytes.

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Mouse Epidermal Growth Factor (EGF)
300-301P

Epidermal Growth Factor (EGF) is a growth factor that stimulates the proliferation of epithelial and epidermal cells. EGF family members are characterized by three intramolecular disulfide bonds and can bind to four different receptor tyrosine kinases known as EGFR/ErbB1, ErbB2, ErbB3, and ErbB4. Recombinant mouse EGF is a non-glycosylated protein, containing 53 amino acids, including 3 intra-moleuclar disulfide-bonds and having a molecular mass of 6 kDa.

Ships ambient. Store frozen at -20 to -10C.

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Mouse Epstein-Barr Virus Induced Gene 3 (IL-27 / EBI-3)
300-302P

Epstein-Barr Virus Induced Gene-3 (EBI3), is a secreted glycoprotein belonging to the hematopoietin receptor family and is related to the p40 subunit of IL-12.  EBI3 was identified by its induced expression in B-lymphocytes in response to Epstein-Barr virus infection.  EBI3 forms heterodimers with p28 to form IL-27 and with p35 to form IL-35.  Both IL-27 and IL-35 have anti-inflammatory and regulatory activity. Recombinant mouse EBI3 is a non-glycosylate protein, consisting of 207 amino acids with a molecular weight of 22.9 kDa.

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Mouse Fibroblast Growth Factor 9 (FGF-9)
300-303P

Fibroblast growth factor-9 (FGF-9) is a steroid-regulated mitogen and survival factor for nerve and mesenchymal cells. FGF-9 is an autocrine/paracrine growth factor considered to be important for the growth and survival of motorneurons and prostate tissue. Recombinant mouse FGF-9 is a non-glycosylated protein, containing 205 amino acids and having a molecular mass of 23.3 kDa.

Ships ambient. Store frozen at -20 to -10C.

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Mouse Fibroblast Growth Factor acidic (FGF-acidic / FGF-1)
300-304P

Fibroblast Growth Factors, FGFs, are a 22 member family of proteins known to be involved in angiogenesis, wound healing and embryonic development. As a family, they bind to heparin and signal through four receptor tyrosine kinases called, FGFR1, 2, 3 and 4. FGF-acidic, or FGF1, is a particularly potent inducer of DNA synthesis and has chemotactic activities. Recombinant mouse FGF-acidic is a non-glycosylated protein, comprised of 141 amino acid residues with a molecular weight of 15.9 kDa.

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Mouse Fibroblast Growth Factor basic (bFGF / FGF-2)
300-305P

Fibroblast Growth Factors, FGFs, are a 22 member family of proteins known to be involved in angiogenesis, wound healing and embryonic development. As a family, they bind to heparin and signal through four receptor tyrosine kinases called, FGFR1, 2, 3 and 4. Although the mechanism remains unclear, FGF-basic is a critical component in keeping embryonic stem cells undifferentiated in cell culture systems. Recombinant mouse FGF is a non-gylcosylated protein, containing 145 amino acids and having a molecular mass of 16.3 kDa.

Ships ambient. Store frozen at -20 to -10C.

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Mouse Flt-3 Ligand (FLT-3 Ligand)
300-306P

Flt3-Ligand is a growth factor important for the proliferation of hematopoietic cells. Flt3-Ligand binds to, and transmits signals through, the receptor tyrosine kinase known as FMS-like Tyrosine Kinase-3 (FLT-3). Flt3 Ligand promotes long-term expansion and differentiation of human pro-B-cells in the presence of IL-7 or in combination of IL-7 and IL-3. Human Flt3-Ligand can stimulate the proliferation of cells expressing murine FLT-3 receptors.Recombinant mouse Flt3-Ligand is a non-glycosylated protein, containing 163 amino acids and having a molecular mass of 18.6 kDa.

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Mouse Granulocyte-Colony Stimulating Factor (G-CSF)
300-307P

Granulocyte Colony-Stimulating Factor, or G-CSF, is a growth factor that is considered the most potent inducer of terminal differentiation to granulocytes and macrophages of leukemic myeloid cell lines. The synthesis of G-CSF can be induced by bacterial endotoxins, TNF, IL-1 and GM-CSF. Prostaglandin E2 inhibits the synthesis of G-CSF, while in epithelial, endothelial, and fibroblastic cells secretion of G-CSF is induced by IL-17. Human and mouse G-CSF are cross-reactive.Recombinant mouse G-CSF is a non-glycosylated protein, containing 179 amino acids, with a molecular weight of 19 kDa.

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Mouse Granulocyte Macrophage-Colony Stimulating Factor (GM-CSF)
300-308P

mGM-CSF is produced in response to a number of inflammatory mediators by mesenchymalcells present in the hemopoietic environment and at peripheral sites of inflammation.It is able to stimulate the production of neutrophilic granulocytes, macrophages and mixed granulocyte-macrophage colonies from bone marrow cells and can stimulate the formation of eosinophil colonies from fetal liver progenitor cells.GM-CSF can also stimulate some functional activities in mature granulocytes and macrophages.GM-CSF receptors show significant homologies with other receptors for hematopoietic growth factors, i

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Mouse Gro-alpha / KC (Gro-α / CXCL1)
300-309P

GRO alpha also known as CXCL1, is a chemokine thought to have mitogenic properties and chemoattract neutrophils. Secreted by macrophages, epithelial cells, neutrophils and melanomas, GRO alpha signals through chemokine receptor, CXCR2, and has been implicated in the processes of spinal cord formation, inflammation, angiogenesis, turmorigenesis , and wound healing. Recombinant mouse GRO-alpha is a non-glycosylated protein, containing 72 amino acids and having a molecular mass of 7.8 kDa.

Ships ambient. Store frozen at -20 to -10C.

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Mouse Insulin-Like Growth Factor I (IGF-I)
300-310P

Insulin-like Growth Factor I, IGF-I, is a growth factor produced in response to growth hormone-stimulated liver and can be found circulating throughout the body and throughout life. IGF-I activates the IGF-I receptor (IGF1R) and the insulin receptor to mediate growth of almost every cell of the body. IGF-I is known as one of the most potent activators of the AKT signaling pathway which is known to be a stimulator of proliferation and an inhibitor of programmed cell death.

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Mouse Interferon gamma (IFN-γ)
300-311P

Interferon gamma, IFN-γ, is a major immune-modulating molecule produced mainly by T-cells and natural killer cells activated by antigens, mitogens or alloantigens. Most immune cells express IFN-γ receptors and respond to IFN-γ-induced signaling by up-regulating MHC class I expression. Human IFN-γ does not show cross-reactivity with mouse. Recombinant mouse IFN-gamma is a non-glycosylated protein, containing 134 amino acids and having a molecular mass of 15.6 kDa.

Ships ambient. Store frozen at -20 to -10C.

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Mouse Interleukin-1 beta (IL-1β)
300-312P

Interleukin-1beta (IL-1β) is a proinflammatory cytokine produced in response to inflammatory agents by a variety of cells, including monocytes, macrophages, and dendritic cells (DCs). IL-1β and IL-1α are two distinct and independently regulated gene products, that comprise IL-1 and signal through the Type 1 IL-1 receptor (IL-1R1).

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Mouse Interleukin-11 (IL-11)
300-313P

Interleukin 11 (IL-11) is a pleotropic cytokine closely related to IL-6 in function, but is overall one of the lesser characterized interleukins. In hematopoietic cell populations, IL-11 is thought to induce megakaryocyte differentiation. In non-hematopoietic populations, IL-11 is thought to be able to stimulate hepatic acute-phase proteins. Human IL-11 can stimulate murine cells. Recombinant mouse IL-11 is a non-glycosylated protein, containing 179 amino acids and having a molecular mass of 19.3 kDa.

Ships ambient. Store frozen at -20 to -10C.

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Mouse Interleukin-13 (IL-13)
300-314P

Interleukin-13 (IL-13) is an important cytokine secreted from Th2 cells. The functions attributed to IL-13 overlap significantly with those of IL-4 (induces IgE secretion from B cells and inhibits expression of inflammatory cytokines such as IL-1β, TNF-α, IL-8 and IL-6), but differs from IL-4 in that IL-13 seems to link inflammatory response of immune cells to the pathophysiological changes in the surrounding non-immune cells. The receptor subunits of IL-13 consist of IL-4Rα, IL-13Rα1 and IL-13Rα2.

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Mouse Interleukin-16 (IL-16)
300-316P

Interleukin 16 (IL-16) is produced primarily by CD4+ and CD8+ T cells and acts as a chemo-attractant for lymphocytes, monocytes, eosinophils, dendritic cells and Langerhans cells. Additionally, IL-16 has been reported to upregulate IL-2 receptor (CD25), induce progression of cells to the GI phase and suppress HIV & SIV replication. Recombinant mouse IL-16 is a non-glycosylated protein, comprised of 127 amino acids, with a molecular weight of 13.2 kDa.

Ships ambient. Store frozen at -20 to -10C.

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Mouse Interleukin-17A (IL-17A)
300-317P

Interleukin-17A (IL-17A), also known as CTLA-8, is a pro-inflammatory cytokine member of a six-species family of proteins (IL-17A-17F).   IL-17A is secreted mainly by activated  CD4+ and CD8+ T lymphocytes and acts through its receptor, IL-17R, to induce the expression of many mediators of inflammation, most importantly, those that are involved in the proliferation, maturation and chemotaxis of neutrophils.  Elevated levels of IL-17A have been associated with several conditions, including rheumatoid arthritis, airway inflammation, allograft rejection, inflammatory boweld

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Mouse Interleukin-17F Heterodimer (IL-17F Heterodimer)
300-318P

Interleukin-17AF (IL-17AF) is a member of the IL-17 family of proteins produced by a subset of T cells, called Th17, following stimulation with IL-23. Since IL-17AF is thought to signal through the IL-17R receptor, its biological function is similar to that of IL-17A in that it induces the production of a variety of chemokines, in addition to airway neutrophilia. In regard to these functions, IL-17AF has less activity than the IL-17A homodimer but, greater activity than the IL-17F homodimer.

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Mouse Interleukin-17E (IL-17E / IL-25)
300-319P

Interleukin-17E (IL-17E), also commonly called IL-25, is a pro-inflammatory cytokine member of a six-species family of proteins (IL-17A-17F). IL-17F stimulates secretion of IL-8 and induces activation of NF-kippa B by binding to the receptor IL-17RB. Recombinant mouse IL-17E is a non-glycosylated, disulfide-linked homodimer. It contains two 145 amino acid peptides and has a total molecular mass of 35.5 kDa.

Ships ambient. Store frozen at -20 to -10C.

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Mouse Interleukin-17F (IL-17F)
300-320P

Interleukin 17F (IL-17F) is one of six members of the IL-17 family (IL-17A-F) secreted by activated CD4+ T cells and monocytes. Similar to IL-17A, IL-17F binds to the IL17 RC receptor and promotes the production of IL-6, IL-8, G-CSF and increases matrix turnover rates. IL-17F is also thought to inhibit angiogenesis and induce endothelial cells to produce IL-2, MCP-1 and TGF-β1. Recombinant mouse IL-17F is a non-glycosylated, disulfide-linked homodimer, containing two 133 amino acid chains, with a total molecular weight of 30 kDa.

Ships ambient. Store frozen at -20 to -10C.

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