Mouse

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Mouse Interleukin IL-31 (IL-31) – Animal Free
300-944P

  Interleukin 31 (IL-31) is an immunoregulatory cytokine that is expressed by activated type 2 T helper (Th2) cells.  IL-31 signals through a heterodimer receptor consisting of the IL-31 Receptor A (IL-31RA) and the oncostatin M receptor (OSMR), which are expressed on monocytes, epithelial cells, and keratinocytes.  IL-31 promotes allergic reactions and inflammatory skin diseases.

This product is produced using Animal Free raw components and processes, in a non-mammalian system.

Ships ambient. Store frozen at -20 to -10°C

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Mouse Interleukin-21 (IL-21) – Animal Free
300-943P

 Interleukin 21 (IL-21) is a member of the common-gamma chain family of cytokines that are involved in immunoregulation. IL-21 is normally expressed by activated CD4+ T cells. The IL-21 receptor (IL-21R) activates the JAK/STAT signaling pathway and is expressed on T, B, and natural killer (NK) cells. Within the B cell lineage, IL-21 is a switch factor regulating IgG1 and IgG3 antibody production. IL-21 also cooperates with interleukin 4 (IL-4) for the production of multiple antibody classes in B cells.

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Human/Mouse Transforming Growth Factor-beta 3 (TGF-β 3) – Animal Free
300-941P

Transforming growth factors (TGFs) are multifunctional peptides that regulate growth and differentiation in most cell types. The TGF-β family of proteins signal through serine/threonine kinase receptors. TGF-β isoforms (TGF-β1, -β2, and –β3) have overlapping, yet distinct biological actions in developing and adult tissues. TGF-β3 is an important factor in regulating cell adhesion and accelerating wound repair. TGF-β3 also functions during osteoblast proliferation, chemotaxis, and collagen synthesis.

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Human/Mouse Neurotrophin-3 (NT-3) – Animal Free
300-940P

Neurotrophin-3 (NT-3) is an important member of the nerve growth factor (NGF) family of proteins. NT-3 promotes the growth, survival, and differentiation of neurons and synapses in the peripheral and central nervous systems. The receptor tyrosine kinase TrkC exclusively binds in high-affinity to NT-3. NT-3 also signals through the receptor tyrosine kinase TrkB, and through the low affinity nerve growth factor receptor (LNGFR).

This product is produced using Animal Free raw components and processes, in a non-mammalian system.

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Human/Mouse Indian Hedgehog (IHH) – Animal Free
300-939P

 Indian hedgehog (IHH) is an essential signaling factor that is secreted in the gut, cartilage, and bone during embryonic development. IHH acts through the patched (PTC) receptor to induce transcriptional changes important for bone and cartilage development. IHH also induces the expression of parathyroid hormone-related peptide (PTHrP), which in turn mediates IHH activity during chondrocyte differentiation, forming a negative feedback loop.

This product is produced using Animal Free raw components and processes, in a non-mammalian system.

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Human/Mouse/Rat Growth and Differentiation Factor-11 (GDF-11) – Animal Free
300-938P

Growth differentiation factor 11 (GDF-11), also known as bone morphogenetic protein 11 (BMP-11), is a regulator of cell growth and differentiation during muscular and neural development. GDF-11 binds the transforming growth factor-beta receptors ALK4, ALK5, and ALK7 to activate SMAD signaling. In adults, exogenous GDF-11 promotes cardiomyocyte regeneration to reverse age-related cardiac hypertrophy.

This product is produced using Animal Free raw components and processes, in a non-mammalian system.

Ships ambient. Store frozen at -20 to -10°C

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Human/Mouse/Rat Bone Morphogenetic Protein-2 (BMP-2) – Animal Free
300-936P

Bone morphogenetic protein 2 (BMP-2 or BMP2) is a member of the bone morphogenetic protein (BMP) family and functions as a potent inducer of bone and cartilage development. BMP proteins are synthesized as large precursor molecules which are cleaved by proteolytic enzymes. Bioactive BMP-2 consists of forming a homodimer or a heterodimer with a related BMP, such as BMP-7. BMP-2 signals through type I and type II receptor tyrosine kinases in conjuction with SMAD proteins to directly promote osteoblast differentiation.

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Human/Mouse/Rat Activin A – Animal Free
300-935P

 Activin A is a member of the transforming growth factor beta (TGF-β) family of proteins and functions to stimulate follicle-stimulating hormone (FSH) secretion.  Activins are produced in many tissue types including the skin, gonads, lungs, and pituitary gland.  Activins interact with receptor type I and type II serine/threonine protein kinases, to activate SMAD signaling and regulate diverse cellular functions, such as cell proliferation, differentiation, wound healing, apoptosis, and metabolism.  Activin A is a homodimer comprised of two activin βA chains.

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Mouse RELM-gamma (RELM γ) – Animal Free
300-921P

Resistin-like molecule-gamma (RELM-γ) is a member of the RELM family of secreted proteins containing C-terminal cysteines. The RELM family consists of Resistin (FIZZ3), RELM-α (FIZZ1), RELM-β (FIZZ2), and RELM-γ (FIZZ4). RELM-γ is secreted by peripheral blood granulocytes, bone marrow, spleen, intestine, and lung. RELM-γ functions to promote and regulate promyelocytic differentiation, in addition to regulating nutrient-associated insulin sensitivity in the intestinal tract.

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Mouse Interleukin-1 alpha (IL-1α / IL-1F1) – Animal Free
300-920P

 Interleukin 1 alpha (IL-1α) is expressed by epithelial cells, activated macrophages, neutrophils, and endothelial cells to regulate immune responses. IL-1α signals through the IL-1 receptor, type 1 (IL-1R1) to activate the myeloid differentiation primary response 88 (MYD88) signaling pathway, which contains the cytoplasmic Toll/IL-1 receptor (TIR) domain adapter.

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Mouse Insulin-like Growth Factor II (IGF-II) – Animal free
300-919P

  Insulin-like growth factor II (IGF-II) is an important fetal growth hormone made by theca cells during gestation.  IGF-II engages the IGF-I receptor (IGF1R) to mediate embryonic growth.  IGF-II also binds the sink IGF-II receptor (IGF2R) leading to IGF-II degradation. 

This product is produced using Animal Free raw components and processes, in a non-mammalian system.

Ships ambient. Store frozen at -20 to -10C

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Mouse Interleukin IL-10 (IL-10) – Animal Free
300-918P

 Interleukin 10 (IL-10) is an anti-inflammatory cytokine produced by macrophages and type 2 T helper (Th2) cells. IL-10 inhibits the production of pro-inflammatory cytokines such as interferon gamma (IFNƴ), tumor necrosis factor alpha (TNFα), interleukin 2 (IL-2), interleukin 3 (IL-3), interleukin 4 (IL-4), and granulocyte-macrophage colony-stimulating factor (GM-CSF), made by macrophages and regulatory T cells. IL-10 also suppresses antigen presentation on antigen presenting cells, and enhances the survival, proliferation, and antibody production of B cells.

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Mouse Interleukin-36 gamma (IL-36 γ) – Animal Free
300-916P

  Interleukin 36 gamma (IL-36 ɣ) is a member of the interleukin 1 (IL-1) cytokine family and protects against pathogens in the skin, lung, and stomach epithelial barriers. IL-36 ɣ binds the interleukin-1 receptor accessory protein (IL-1RAcP) and the orphan IL-1R-related protein 2 (IL-1Rrp2) receptors to activate NF-kB and MAP kinase signaling pathways, resulting in the induced production of inflammatory cytokines and chemokines.

This product is produced using Animal Free raw components and processes, in a non-mammalian system.

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Mouse Interleukin-17A (IL-17A) – Animal Free
300-915P

 Interleukin 17A (IL-17A), also known as CTLA-8, is a member of the IL-17 family of proteins.  IL-17A is a proinflammatory cytokine that is secreted by activated CD4+ and CD8+ T lymphocytes.  IL-17A acts through its receptor, IL-17R, to promote increased cytokine and chemokine secretion.

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Mouse Tumor Necrosis Factor-alpha (TNF-α) – Animal Free
300-914P

Tumor necrosis factor alpha (TNF-α) is an inflammatory cytokine secreted by macrophages, monocytes, neutrophils, T cells, and NK-cells following stimulation by bacterial lipopolysaccharide (LPS). TNF-α signal activation occurs through two receptors, TNFR1 and TNFR2. TNFR1 is expressed on most cell types, unlike TNFR2, which is expressed mainly on immune cells. TNF-α functions to stimulate phagocytosis in macrophages, chemoattract neutrophils, increase insulin resistance, and induce fever.

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Mouse Leptin – Animal Free
300-913P

 Leptin is a hormone that is produced by adipose tissue and plays critical roles in the physiologic regulation of body weight. Leptin acts through the leptin receptor (LEPR) to regulate adipose mass by inhibiting hunger and balancing energy usage. Leptin mutations cause severe hereditary obesity and hypogonadism in rodents and humans. Leptin also has thermogenic actions, regulates enzymes of fatty acid oxidation, and is involved in hematopoiesis, angiogenesis, wound healing, inflammation, and immune responses.

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Mouse Interleukin-2 (IL-2) – Animal Free
300-912P

 Interleukin 2 (IL-2) is an immunomodulatory cytokine that is produced by lymphocytes.  IL-2 signals through the IL-2R receptor to induce activated T cell proliferation and promote T cell differentiation. IL-2 also stimulates the proliferation and differentiation of B cells, natural killer cells, monocytes, and macrophages.

This product is produced using Animal Free raw components and processes, in a non-mammalian system.

Ships ambient. Store frozen at -20 to -10C

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Mouse Interferon-gamma (IFN-γ) – Animal Free
300-911P

Interferon gamma (IFN-γ) is a type II interferon that is critical during adaptive and innate immune responses to infection. IFN-γ is produced by T cells and natural killer cells following antigen-specific activation. IFN-γ binds IFN-γ receptors (IFN-γ R1 and IFN-γ R2), which are expressed on most immune cells, to activate the JAK-STAT pathway. IFN-γ-induced signaling increases the expression of class 1 major histocompatibility complex (MHC) molecules. Mouse IFN-γ is not cross-reactive with human IFN-γ.

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Mouse Fibroblast Growth Factor-9 (FGF-9) – Animal Free
300-910P

 Fibroblast growth factor 9 (FGF-9) is a mitogen and survival factor for nerve and mesenchymal cells. FGF-9 functions as an autocrine and paracrine factor to support the growth and survival of motor neurons and prostate tissue. FGF-9 expression in the gonad is also necessary for sex determination.

This product is produced using Animal Free raw components and processes, in a non-mammalian system.

Ships ambient. Store frozen at -20 to -10C

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Mouse Fibroblast Growth Factor-basic (FGF-basic / FGF-2) – Animal Free
300-909P

 Basic fibroblast growth factor (FGF-basic), also known as FGF-2, is expressed by endothelial cells and is a mediator of angiogenesis. FGF-basic also has cardioprotective functions during heart injury. The application of FGF-basic is a critical component for human embryonic stem cell culture systems and is necessary for maintaining human embryonic stem cells in an undifferentiated state.

This product is produced using Animal Free raw components and processes, in a non-mammalian system.

Ships ambient. Store frozen at -20 to -10C

*Single-unit price. For inquiries about this product, contact your sales representative.