Mouse

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Mouse Interleukin-27 (IL-27 / p28) (Animal Free)
300-829P

The p28 subunit of IL-27 (IL-27/p28), also known as Interleukin-30 (IL-30), is a member of the IL-12 family of cytokines. When combined with EBI3 (Epstein-Barr virus induced gene 3), p28 forms a heterodimer known as IL-27. p28 is thought to be a pro-inflammatory cytokine inducing immuno-modulatory effects, but the details of these effects are currently unclear and research is focused on delineating its specific biological functions. Recombinant mouse p28 is a non-glycosylated protein, containing 207 amino acids, with a molecular weight of 23.7 kDa.

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Mouse Glial Derived Neurotrophic Factor (GDNF Animal Free)
300-830P

Glial Cell Line-Derived Neurotrophic Factor, or GDNF, is a neurotrophic factor that is closely related to other neurotrophic factors such as Neurturin, Persephin, and Artemin, by a common structural feature called the cysteine-knot. GDNF signals through a multicomponent system of receptors that includes receptors known as RET, and GFRα1-4 to promote dopamine uptake, survival and differentiation of neurons. Recombinant mouse GDNF is a non-glycosylated homodimer, containing two 135 amino acid chains, with a total molecular weight of 30.2 kDa.

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Mouse Interleukin-11 (IL-11 Animal Free)
300-833P

Interleukin 11 (IL-11) is a pleotropic cytokine closely related to IL-6 in function, but is overall one of the lesser characterized interleukins. In hematopoietic cell populations, IL-11 is thought to induce megakaryocyte differentiation. In non-hematopoietic populations, IL-11 is thought to be able to stimulate hepatic acute-phase proteins. Human IL-11 can stimulate murine cells. Recombinant mouse IL-11 is a non-glycosylated protein, containing 179 amino acids and having a molecular mass of 19.3 kDa.

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Mouse Leukemia Inhibitory Factor (mLIF) Powder – Animal Free
300-838P

Mouse Leukemia Inhibitory Factor (LIF) is member of the IL-6 family and is made by a variety of tissues.  LIF signals through receptors gp190 (LIFR) and gp130 to activate STAT3 which ultimately promotes mouse embryonic stem cell self-renewal and pluripotentcy of long term cultures.  This activity is similar to that attributed to FGF-basic (FGF-2) for human embryonic stem cells. 

This product is produced using Animal Free raw components and processes, in a non-mammalian system.

Ships ambient. Store frozen at -20 to -10C.

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Mouse Interleukin-33 (IL-33 Animal Free)
300-841P

Interleukin 33 (IL-33) is a member of the IL-1 cytokine family and is constitutively expressed in smooth muscle cells and the airway epithelium. IL-33 signals through receptors, IL-1RL1 and IL-1RAP, to induce type 2 cytokine production in polarized Th2 cells. Recombinant mouse IL-33 is a non-glycosylated protein, containing 159 amino acids, with a molecular weight of 17.7 kDa.

This product is produced using Animal Free raw components and processes, in a non-mammalian system.

Ships ambient. Store frozen at -20 to -10C.

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Product 100 μg $105500 μg $2441 Mg Inquire5 Mg Inquire

Mouse Epidermal Growth Factor (EGF) – Animal Free
300-845P

Epidermal Growth Factor (EGF) is a growth factor that stimulates the proliferation of epithelial and epidermal cells.  EGF family members are characterized by three intramolecular disulfide bonds and can bind to four different receptor tyrosine kinases known as EGFR/ErbB1, ErbB2, ErbB3, and ErbB4.  Recombinant mouse EGF is a non-glycosylated protein, containing 53 amino acids, including 3 intra-molecular disulfide-bonds, with a molecular weight of 6 kDa.

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Mouse Macrophage Colony-Stimulating Factor (M-CSF Animal Free)
300-847P

Macrophage Colony Stimulating Factor (M-CSF) is hematopoietic growth factor produced by a wide variety of cells.  M-CSF is known to stimulate differentiation of hematopoietic stem cells to monocyte-macrophagecell populations in culture. M-CSF acts through the CSF receptor 1.  Although human M-CSF shows activity on mouse cells, mouse CSF shows no activity on human cells.  Recombinant mouse M-CSF is a disulfide-linked homodimer, containing two 156 amino acid chains, with a total molecular weight of 36.4 kDa.

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Mouse Thrombopoietin (TPO Animal Free)
300-848P

Thrombopoietin (TPO) is a growth factor that is produced by the liver and kidney. TPO acts through theTPO receptor to promote megakaryocyte maturation and differentiation, which leads to the production of platelets.  Recombinant mouse TPO is a non-glycosylated protein, containing 174 amino acids (which comprise the receptor binding domain), having a molecular mass of 18.7 kDa.  

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Mouse Interleukin-5 (IL-5) – Animal Free
300-856P

Interleukin-5 (IL-5) is a hematopoietic growth factor expressed in Th2, mast cells and eosinophils. IL-5 acts through its receptor, the IL-5 receptor (IL-5R) and is involved in B-cell growth and eosinophil activation. IL-5 has been shown to be and is regulated by GATA-3, in addition to other transcription factors. Human and mouse IL-5 are cross-reactive. Recombinant mouse IL-5 is a non-glycosylated, disulfide-linked homodimer. It is comprised of two 113 amino acid chains with a total molecular weight of 26.2 kDa.

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Mouse Interleukin-17E (IL-17E / IL-25) – Animal Free
300-865P

Interleukin-17E (IL-17E), also commonly called IL-25, is a pro-inflammatory cytokine member of a six-species family of proteins (IL-17A-17F). IL-17F stimulates secretion of IL-8 and induces activation of NF-kippa B by binding to the receptor IL-17RB. Recombinant mouse IL-17E is a non-glycosylated, disulfide-linked homodimer. It contains two 145 amino acid peptides and has a total molecular mass of 35.5 kDa.

This product is produced using Animal Free raw components and processes, in a non-mammalian system.

Ships ambient. Store frozen at -20 to -10C.

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Mouse Interleukin-17F (IL-17F) – Animal Free
300-866P

Interleukin 17F (IL-17F) is one of six members of the IL-17 family (IL-17A-F) secreted by activated CD4+ T cells and monocytes. Similar to IL-17A, IL-17F binds to the IL17 RC receptor and promotes the production of IL-6, IL-8, G-CSF and increases matrix turnover rates. IL-17F is also thought to inhibit angiogenesis and induce endothelial cells to produce IL-2, MCP-1 and TGF-β1. Recombinant mouse IL-17F is a non-glycosylated, disulfide-linked homodimer, containing two 133 amino acid chains, with a total molecular weight of 30 kDa.

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Mouse Interleukin-19 (IL-19) – Animal Free
300-867P

Interleukin-19 (IL-19) is produced by resting B cells and monocytes.  IL-19 can be up-regulated when monocytes are treated with GM-CSF or LPS.  IL-19 shares a receptor complex with IL-20, and acts to induce IL-6 and TNF-α production by monocytes as well as to promote a Th2 response.  

This product is produced using Animal Free raw components and processes, in a non-mammalian system.

Ships ambient. Store frozen at -20 to -10C.

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Mouse Interleukin-22 (IL-22) – Animal Free
300-868P

Interleukin-22 (IL-22), also called IL-TIF, is produced by activated dendritic cells and T lymphocytes.  IL-22 signals via the IL-22R and IL-10Rbeta receptors to act as a potent mediator of the cellular inflammatory response and wound healing.  

This product is produced using Animal Free raw components and processes, in a non-mammalian system.

Ships ambient. Store frozen at -20 to -10C.

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Mouse Migration Inhibitory Factor (MIF) – Animal Free
300-870P

Macrophage Migration Inhibitory Factor (MIF) is a pro-inflammatory cytokine that acts by inducing IL-1, IL-8 and MMP expression. MIF stimulates NO production and TNF-α release following IFNγ-activation of macrophages. 

This product is produced using Animal Free raw components and processes, in a non-mammalian system.

Ships ambient. Store frozen at -20 to -10C.

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Mouse Soluble RANK Ligand – Animal Free
300-871P

Receptor Activator of NF-kappa B Ligand (RANKL) is a cell-bound marker (CD254) related to the TNF family of proteins. RANKL plays a critical role in bone metabolism, particularly osteoclast differentiation. In addition, RANKL is expressed by some T cells is thought to promote dendritic cell maturation. Recombinant mouse soluble RANK Ligand is a non-glycosylated protein, containing 174 amino acids and having a molecular weight of 19.9 kDa.

This product is produced using Animal Free raw components and processes, in a non-mammalian system.

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Mouse Interleukin-6 (IL-6) – Animal Free
300-903P

Interleukin 6 (IL-6) is a cytokine that is expressed by T cells, macrophages, and muscle cells. IL-6 acts to stimulate an immune response upon infection or trauma. IL-6 has both pro-inflammatory and anti-inflammatory functions, is capable of promoting fever, and signals through the cell-surface type I cytokine receptor complex containing the IL-6Ra and gp130 chains. Human IL-6 is active on mouse and rat cells.

This product is produced using Animal Free raw components and processes, in a non-mammalian system.

Ships ambient. Store frozen at -20 to -10C

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Mouse Interleukin-7 (IL-7) – Animal Free
300-904P

 Interleukin 7 (IL-7) is a hematopoietic cytokine that is an important regulator of B and T cell development. IL-7 is secreted by bone marrow and thymic stromal cells, dendritic cells, intestinal epithelial cells, hepatocytes, and keratinocytes. IL-7 signals through the interleukin 7 receptor (IL-7R) to promote the differentiation of hematopoietic stem cells into T cells, B cells, and natural killer cells. IL-7 is also a regulator of intestinal mucosal lymphocyte proliferation. Human and mouse IL-7 show species cross-reactivity.

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Mouse Flt-3 Ligand (FLT-3 Ligand) – Animal Free
300-905P

 Fms-related tyrosine kinase 3 ligand (FLT-3 ligand) is a growth factor that regulates hematopoietic cell proliferation. FLT-3 ligand signalling is transmitted through the fms-related tyrosine kinase 3 (FLT-3) receptor. FLT-3 ligand promotes the long-term expansion and differentiation of pro-B cells in the presence of interleukin 7 (IL-7,) or in combination of IL-7 and interleukin 3 (IL-3).

This product is produced using Animal Free raw components and processes, in a non-mammalian system.

Ships ambient. Store frozen at -20 to -10C

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Mouse Stem Cell Factor (SCF) — Animal Free
300-906P

 Stem cell factor (SCF) is a cytokine made by fibroblasts and endothelial cells. SCF binds to the receptor c-Kit/CD117 and plays a critical role in the maintenance, survival, and differentiation of hematopoietic stem cells. While human SCF shows no activity on murine cells, murine and rat SCF are active on human cells.

This product is produced using Animal Free raw components and processes, in a non-mammalian system.

Ships ambient. Store frozen at -20 to -10C

*Single-unit price. For inquiries about this product, contact your sales representative.