The chemokine IP-10 (or CXCL10) is a chemokine made by monocytes, endothelial cells and fibroblasts in response to treatment with IFNγ.  IP-10 functions as a chemoattractant to cells expressing the G protein-coupled receptor, CXCR3, which is found mainly on activated T cells and NK cells.  IP-10 plays an important role in Th1 type inflammatory diseases and autoimmune diseases such as Hashimoto’s thyroiditis, Graves’ disease and Type 1 diabetes mellitus.  Recombinant guinea pig IP-10 is a non-glycosylated protein, containing 76 amino acids, with a molecular weight of 8.65 kDa.

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