Human Interleukin-8 (IL-8 / CXCL8)

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Interleukin 8 (IL-8 or CXCL8) is an inflammatory chemokine of the CXC family that can be produced by a variety of cells but is predominantly studied in the context of macrophages and epithelial cells.  IL-8 is a ligand for GPCRs, CXCR1 and CXCR2, and acts to recruit innate immune cells as well as induce phagocytosis.  IL-8 is also able to induce angiogenesis. 

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