Myostatin is a member of the TGF-β superfamily that is essential for proper regulation of skeletal muscle mass in a number of species ranging from fish to humans. Myostatin is a secreted protein that negatively regulates skeletal muscle mass determining both muscle fiber number and size. Inhibition of myostatin can increase muscle mass in a number of animal models of human disease, including muscular dystrophy. Recombinant human myostatin is a non-glycosylated homodimer, containing two 109 amino acids and having a total molecular mass of 24.8 kDa.
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