Human Neuregulin 1-beta (NRG1-β)
Neuregulin 1-beta (NRG1) is one of many isoforms of NRG that contains a soluble EGF-like domain. Alpha and beta varients are distinguished by difference in length at the C terminus. The EGF-like domain signals through receptors ErbB2, ErbB3, and ErbB4 to act as a growth factor. NRG isoforms are particularly important for nervous system and cardiovasucular development. Recombinant human NRG1-beta is a non-glycosylated protein, containing 66 amino acids, with a molecular weight of 7.6 kDa.
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