Human R-Spondin 1
R-Spondin 1 (RSPO-1)is a secreted growth factor that stabilizes β-catenin and enhances WNT signaling. RSPO-1 is expressed in many tissues and regulates female sex determination, XX gonad development, oocyte differentiation, and hematopoietic stem cell specification. The RSPO-1 stabilization of β-catenin promotes intestinal crypt cell proliferation. This suggests that RSPO-1 functions as a stem cell growth factor and may have therapeutic potential in the treatment of gastrointestinal diseases and chemotherapy-induced intestinal mucositis. Additionally, recombinant RSPO-1 is a critical protein used to establish 3D intestinal organoid cultures (stomach, small intestine, colon, pancreas, and liver sources). Shenandoah is a manufacturer that offers an affordable option of recombinant RSPO-1 protein.
Ships ambient. Store frozen at -20 to -10C.
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