Human R-Spondin 1

Product 5 μg $9625 μg $221100 μg Inquire500 μg Inquire1Mg Inquire

 R-Spondin 1 (RSPO-1)is a secreted growth factor that stabilizes β-catenin and enhances WNT signaling.  RSPO-1 is expressed in many tissues and regulates female sex determination, XX gonad development, oocyte differentiation, and hematopoietic stem cell specification.  The RSPO-1 stabilization of β-catenin promotes intestinal crypt cell proliferation.  This suggests that RSPO-1 functions as a stem cell growth factor and may have therapeutic potential in the treatment of gastrointestinal diseases and chemotherapy-induced intestinal mucositis.  Additionally, recombinant RSPO-1 is a critical protein used to establish 3D intestinal organoid cultures (stomach, small intestine, colon, pancreas, and liver sources).  Shenandoah is a manufacturer that offers an affordable option of recombinant RSPO-1 protein.

Ships ambient. Store frozen at -20 to -10C.

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