Granulocyte Macrophage Colony Stimulating Factor, GM-CSF, is hematopoietic factor produced by endothelial cells, monocytes, fibroblasts and T cells in response to a number of inflammatory mediators. GM-CSF is able to stimulate the production of neutrophilic granulocytes, macrophages, and mixed granulocyte-macrophage colonies from bone marrow cells. GM-CSF can also stimulate some functional activities in mature granulocytes and macrophages.Human and mouse GM-CSF show no cross-reactivity.  Recombinant rat GM-CSF is a non-glycosylated protein, containing 128 amino acids and has a predicted molecular weight of 14.6 kDa.

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