Interleukin-17A (IL-17A), also known as CTLA-8, is a pro-inflammatory cytokine member of a six-species family of proteins (IL-17A-17F).   IL-17A is secreted mainly by activated  CD4+ and CD8+ T lymphocytes and acts through its receptor, IL-17R, to induce the expression of many mediators of inflammation, most importantly, those that are involved in the proliferation, maturation and chemotaxis of neutrophils.  Elevated levels of IL-17A have been associated with several conditions, including rheumatoid arthritis, airway inflammation, allograft rejection, inflammatory boweldisease, psoriasis, cancer and multiple sclerosis.  Human, mouse and rat IL-17A show activity on mouse cells.    Recombinant rat IL-17A is a non-glycosylated, disulfide-joined homodimer, having a total molecular mass of 30 kDa.

Ships ambient. Store frozen at -20 to -10C.