Rat

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Rat Fibroblast Growth Factor-9 (FGF-9)
300-500P

Fibroblast growth factor-9 (FGF-9) is a steroid-regulated mitogen and survival factor for nerve and mesenchymal cells. FGF-9 is an autocrine/paracrine growth factor considered to be important for the growth and survival of motorneurons and prostate tissue.  Recombinant rat FGF-9 is a non-glycosylated protein, containing 205 amino acids and has a molecular mass of 23.3 kDa.

Ships ambient. Store frozen at -20 to -10C.

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Rat Granulocyte Macrophage-Colony Stimulating Factor (GM-CSF)
300-501P

Granulocyte Macrophage Colony Stimulating Factor, GM-CSF, is hematopoietic factor produced by endothelial cells, monocytes, fibroblasts and T cells in response to a number of inflammatory mediators. GM-CSF is able to stimulate the production of neutrophilic granulocytes, macrophages, and mixed granulocyte-macrophage colonies from bone marrow cells.

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Rat Insulin Like Growth Factor I (IGF-I)
300-502P

Insulin-like Growth Factor I, IGF-I, is a growth factor produced in response to growth hormone-stimulated liver and can be found circulating throughout the body and throughout life. IGF-I activates the IGF-I receptor (IGF1R) and the insulin receptor to mediate growth of almost every cell of the body.

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Rat Interferon gamma (IFN-γ)
300-503P

Interferon gamma, IFN-γ, is a major immune-modulating molecule produced mainly by T-cells and natural killer cells activated by antigens, mitogens or alloantigens. Most immune cells express IFN-γ receptors and respond to IFN-γ-induced signaling by up-regulating MHC class I expression. Recombinant rat  IFN gamma is a non-glycosylated protein, containing 135 amino acids and has a predicted molecular weight of 15.6 kDa.

Ships ambient. Store frozen at -20 to -10C.

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Rat Interleukin-1 beta (IL-1 β)
300-504P

Interleukin-1 beta (IL-1β) is a proinflammatory cytokine, produced in response to inflammatory agents by a variety of cells, including, monocytes, macrophages, and dendritic cells (DCs). IL-1β and IL-1α are two distinct and independently regulated gene products that comprise IL-1 and signal through the Type 1 IL-1 receptor (IL-1R1).

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Rat Interleukin-17A (IL-17A)
300-505P

Interleukin-17A (IL-17A), also known as CTLA-8, is a pro-inflammatory cytokine member of a six-species family of proteins (IL-17A-17F).   IL-17A is secreted mainly by activated  CD4+ and CD8+ T lymphocytes and acts through its receptor, IL-17R, to induce the expression of many mediators of inflammation, most importantly, those that are involved in the proliferation, maturation and chemotaxis of neutrophils.  Elevated levels of IL-17A have been associated with several conditions, including rheumatoid arthritis, airway inflammation, allograft rejection, inflammatory boweld

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Rat Interleukin-17AF Heterodimer (IL-17AF Heterodimer)
300-506P

Interleukin-17AF (IL-17AF) is a member of the IL-17 family of proteins produced by a subset of T cells, called Th17, following stimulation with IL-23. Since IL-17AF is thought to signal through the IL-17RA receptor, its biological function is similar to that of IL-17A in that it induces the production of a variety of chemokines, in addition to airway neutrophilia.

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Rat Interleukin-17E (IL-17E / IL-25)
300-507P

Interleukin-17E (IL-17E), also commonly called IL-25, is a pro-inflammatory cytokine member of a six-species family of proteins (IL-17A-17F). IL-17F stimulates secretion of IL-8 and induces activation of NF-kappaB by binding to the receptor IL-17RB.  Recombinant rat IL-17E is a non-glycosylated, disulfide-linked homodimer, containing two 145 amino acid proteins and having a total molecular mass of 35.5 kDa.

Ships ambient. Store frozen at -20 to -10C.

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Rat Interleukin-17F (IL-17F)
300-508P

Interleukin 17F (IL-17F) is one of six members of the IL-17 family (IL-17A-F) secreted by activated CD4+ T cells and monocytes. Similar to IL-17A, IL-17F binds to the IL17 RC receptor and promotes the production of IL-6, IL-8, G-CSF and increases matrix turnover rates. IL-17F is also thought to inhibit angiogenesis and induce endothelial cells to produce IL-2, MCP-1 and TGF-β1.

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Rat Interleukin-6 (IL-6)
300-509P

Interleukin-6 (IL-6) is an important pro-inflammatory and anti-inflammatory cytokine expressed by T-cells, macrophages and muscle cells. IL-6 signals through a receptor complex containing two receptors, IL-6Rα and gp130. IL-6 has an important function in promoting fever and can serve to stimulate an immune response to trauma. IL-6 is often used for growth of hybridoma cell lines. Human IL-6 is active on mouse and rat cells.  Recombinant rat IL-6 is a non-gylcosylated protein, containing 187 amino acids and has a predicted molecular weight of 21.7 kDa.

Ships ambient.

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Rat Leptin
300-510P

Leptin a protein that is thought to have a critical role in the physiologic regulation of body weight via its capacity to inhibit food intake and stimulate energy expenditure. Leptin also has thermogenic actions and regulates enzymes of fatty acid oxidation.

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Rat Macrophage Inflammatory Protein-1 alpha (MIP-1α / CCL3)
300-511P

Macrophage Inflammatory Protein-1 alpha (MIP-1α), also known as CCL3, is produced by macrophages and is thought to induce inflammatory responses, including superoxide production by neutrophils. MIP-1α can exist as a naturally occurring heterodimer with MIP-1β and has been shown to have antiviral activity against HSV-1.  Recombinant rat MIP-1α is a non-glycosylated protein, containing 69 amino acids and having a molecular mass of 7.8 kDa.

Ships ambient. Store frozen at -20 to -10C.

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Rat monocyte Chemotactic Protein-1 (MCP-1 / CCL2)
300-512P

Monocyte Chemotactic Protein 1 (MCP-1), also known as CCL2, is thought to be produced by injured or infected tissues. MCP-1 signals through G protein-coupled receptors, CCR2 and CCR4, to recruit memory T cells, monocytes and dendritic cells.  Recombinant rat MCP-1 is a non-glycosylated protein, containing 125 amino acids and having a molecular mass of 14.1 kDa.

Ships ambient. Store frozen at -20 to -10C.

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Rat Stem Cell Factor (SCF)
300-514P

Stem Cell Factor (SCF) is a cytokine made by fibroblasts and endothelial cells. SCF binds to the receptor known as c-Kit (CD117) and is thought to play a critical role in the maintenance or survival of hematopoietic stem cells. Human SCF shows no activity on murine cells, but murine and rat SCF are active on human cells.  Recombinant rat SCF is a non-glycosylated protein, containing 165 amino acids and having a molecular mass of 18.4 kDa.

Ships ambient. Store frozen at -20 to -10C.

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Rat Vascular Endothelial Growth Factor-165 (VEGF-165)
300-516P

Vascular Endothelial Growth Factor-A (VEGF-A) was originally isolated from tumor cells and is produced by a wide variety of cell types. In addition to stimulating vascular growth and vascular permeability, VEGF-A may play a role in stimulating vasodilatation via nitric oxide-dependent pathways. VEGF-A has several variants, VEGF-165 being the most abundant.

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Rat Epidermal Growth Factor (EGF)
300-518P

Epidermal Growth Factor (EGF) is a growth factor that stimulates the proliferation of epithelial and epidermal cells. EGF family members are characterized by three intramolecular disulfide bonds and can bind to four different receptor tyrosine kinases known as EGFR/ErbB1, ErbB2, ErbB3, and ErbB4. Recombinant rat EGF is a non-glycosylated protein, containing 54 amino acids, with a molecular weight of 6.3 kDa.

Ships ambient. Store frozen at -20 to -10C.

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Rat Monocyte Chemotactic Protein-3 (CCL7)
300-519P

Monocyte Chemotactic Protein 3 (MCP-3), also called CCL7, is chemokine produced by macrophages and some tumor cell lines. MCP-3 signals through three different G protein-coupled receptors, CCR1, CCR2, and CCR3. CCL7 chemoattracts monocytes and can regulate macrophage function. Recombinant rat MCP-3 is a non-glycosylated protein, containing 75 amino acids, with a molecular weight of 8.6 kDa.

Ships ambient. Store frozen at -20 to -10C.

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Rat Fibroblast Growth Factor-basic (FGF-basic)
300-520P

Fibroblast Growth Factors (FGFs) are a 22 member family of proteins known to be involved in angiogenesis, wound healing and embryonic development. As a family, they bind to heparin and signal through four receptor tyrosine kinases called, FGFR1, 2, 3 and 4. Recombinant rat FGF-basic is a non-glycosylatedprotein, containing 146 amino acids, with a molecular weight of 16.4 kDa.

Ships ambient. Store frozen at -20 to -10C.

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Rat Glial Derived Neurotrophic Factor (GDNF)
300-521P

Glial Cell Line-Derived Neurotrophic Factor, or GDNF, is a neurotrophic factor that is closely related to other neurotrophic factors such as Neurturin, Persephin, and Artemin, by a common structural feature called the cysteine-knot. GDNF signals through a multicomponent system of receptors that includes receptors known as RET, and GFRα1-4 to promote dopamine uptake, survival and differentiation of neurons.  Recombinant rat GDNF is a non-glycosylated homodimer, containing two 135 amino acid chains, with a total molecular weight of 30.1 kDa.

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