Interleukin-17A (IL-17A), also known as CTLA-8, is a
pro-inflammatory cytokine member of a six-species family of
proteins (IL-17A-17F). IL-17A is secreted mainly by
activated CD4+ and CD8+ T lymphocytes and acts through its
receptor, IL-17R, to induce the expression of many mediators of
inflammation, most importantly, those that are involved in the
proliferation, maturation and chemotaxis of neutrophils.
Elevated levels of IL-17A have been associated with several
conditions, including rheumatoid arthritis, airway inflammation,
allograft rejection, inflammatory boweld
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