Case study: Uniquely allowing large fold expansion of adherent cells with no passaging in a GMP compliant bioreactor system
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Case study: Uniquely allowing large fold expansion of adherent cells with no passaging in a GMP compliant bioreactor system

We present anonymized data from an ongoing collaboration that demonstrates our ability to eliminate passaging (cell harvest and reseeding) and go from small cell numbers (<1 million) to clinically relevant numbers (as high as 2 billion) in one closed device with simple to use microcarriers. We show how our microcarrier-based culture offers an effective solution to process scale up in our closed system. 

The capability to take full samples (cells, not just medium) allows users to do quality checks on their cell product at any point in the culture cycle to ensure the process is working. This system allows full visibility into process monitoring and control options (pH, oxygen, temperature, and biomass). It also saves users costs for cell therapy production by significantly reducing the involved labor, consumable use, and cleanroom requirements. Learn more about how the Scinus Bioreactor can achieve a clinically relevant number of cells.