Guest speaker Dr. Natasha Sheybani from the University of Virginia introduces a disruptive, emerging therapeutic technology for non-invasive, non-ionizing acoustic energy deposition into tumors: focused ultrasound (FUS). We explore how FUS is being leveraged to potentiate immune modulation, extracellular vesicle modulation and drug delivery in solid tumors. We cover a diverse array of pre-clinical and clinical applications at the cutting edge of FUS immunotherapy that span such settings as triple negative breast cancer and glioblastoma.